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Bardet Biedl Syndrome is a rare genetic disorder with highly variable symptoms which may include retinal degeneration, obesity, reduced kidney function, polydactyly extra digits of the hands or feet among many other features. While there are more than 20 genes associated with BBS, the underlying cause regardless of gene is malfunction of primary cilia, a key component of cellular communication. BBS is thus categorized as a ciliopathy, or a disease of the cilia. Before the genetic and molecular basis of BBS was discovered, it could only be recognized as a set of symptoms.
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Once logged in, the user can perform functions such as uploading and downloading software and data, reading news and bulletins, and exchanging messages with other users through public message boards and sometimes via direct chatting. In the early s, message networks such as FidoNet sprung up to provide services such as NetMail, which is similar to email. Many BBSes also offer online games in which users can compete with each other. BBSes with multiple phone lines often provide chat rooms , allowing users to interact with each other. Bulletin board systems were in many ways a precursor to the modern form of the World Wide Web , social networks , and other aspects of the Internet. Low-cost, high-performance modems drove the use of online services and BBSes through the early s. InfoWorld estimated that there were 60, BBSes serving 17 million users in the United States alone in , a collective market much larger than major online services such as CompuServe.
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